PUBLICATIONS – Lehui Group

******************Selected Publications ******************

19. Liu, H.; Geng, X.; Wang, X.; Wei, L.; Li, Z.; Lin, S.; Xiao, L.*, A Carbonized Fluorescent Nucleolus Probe Discloses RNA Reduction in the Process of Mitophagy. CCS Chemistry 2021, 3, 3081–3093. https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101371

18. Gen, W.-C.; Ye, Z.; Zheng, Z.; Gao, J.; Li, J.-J.; Shah, M. R.; Xiao, L.*; Guo, D.-S.* Supramolecular Bioimaging through Signal Amplification by Combining Indicator Displacement Assay with Förster Resonance Energy Transfer. Angew. Chem. Int. Ed. 2021, 60, 19766 –19771. https://doi.org/10.1002/anie.202104358

17. Wang, X.; Ye, Z.; Hua, J.; Wei, L.; Lin, S.; Xiao, L.*, Fast Surface Restructuring within the Gap of Au Nanocube Dimer for the Enhancement of Catalytic Efficiency. CCS Chemistry 2021, 3, 1185-1197. https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202100770

16. Ye, Z.; Geng, X.; Wei, L.; Li, Z.; Lin, S.; Xiao, L.*, Length Dependent Distinct Cytotoxic Effect of Amyloid Fibrils beyond Optical Diffraction Limit Revealed by Nanoscopic Imaging. ACS Nano 2021, 15, 934-943. https://pubs.acs.org/doi/abs/10.1021/acsnano.0c07555

15. Xu, J.; Wang, J.; Qiu, J.*; Liu, H.; Wang, Y.; Cui, Y.; Humphry, R.; Wang, N.; Durkan, C.; Chen, Y.; Lu, Y.; Ma, Q.; Wu, W.; Luo, Y.; Xiao, L.*; Wang, G.*, Nanoparticles Retard Immune Cells Recruitment in vivo by Inhibiting Chemokine Expression. Biomaterials 2021, 265, 120392. https://www.sciencedirect.com/science/article/pii/S0142961220306384

14. Yan, Z.; Wang, D.; Ye, Z.; Fan, T.; Wu, G.; Deng, L.; Yang, L.; Li, B.; Liu, J.; Ma, T.; Dong, C.; Li, Z.; Xiao, L.*; Wang, Y.*; Wang, W.*; Hou, J.*, Artificial Aquaporin That Restores Wound Healing of Impaired Cells. J. Am. Chem. Soc. 2020, 142, 15638–15643. https://pubs.acs.org/doi/10.1021/jacs.0c00601

13. Ma, Y.; Ye, Z.; Zhang, C.; Wang, X.; Li, H.; Wang, M. S.; Luo, H.*; Xiao, L.*, Deep Red Blinking Fluorophore for Nanoscopic Imaging and Inhibition of β-Amyloid Peptide Fibrillation. ACS Nano 2020, 14, 11341–11351. https://pubs.acs.org/doi/10.1021/acsnano.0c03400

12. Ye, Z.; Wei, L.; Geng, X.; Wang, X.; Li, Z.; Xiao, L.*, Mitochondrion-Specific Blinking Fluorescent Bioprobe for Nanoscopic Monitoring of Mitophagy. ACS Nano 2019, 13, 11593-11602. https://pubs.acs.org/doi/10.1021/acsnano.9b05354

11. Ling, Y.; Zhang, D.; Cui, X.; Wei, M.; Zhang, T.; Wang, J.; Xiao, L.*; Xia, Y.*, Direct Monitoring Cell Membrane Vesiculation with 2D AuNP@MnO2 Nanosheet Supraparticles at Single-Particle Level. Angew. Chem. Int. Ed. 2019, 58, 10542-10546. https://doi.org/10.1002/anie.201902987

10. Ye, Z.; Wei, L.; Xiao, L.*; Wang, J., Laser Illumination-Induced Dramatic Catalytic Activity Change on Au Nanospheres. Chem. Sci. 2019, 10, 5793-5800. https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc01666j#!divAbstract

9. Ye, Z.; Liu, H.; Wang, F.; Wang, X.; Wei, L.; Xiao, L.*, Single-Particle Tracking Discloses Binding-Mediated Rocking Diffusion of Rod-Shaped Biological Particles on Lipid Membranes. Chem. Sci. 2019, 10, 1351-1359. https://pubs.rsc.org/en/content/articlelanding/2019/SC/C8SC04033H#!divAbstract

8. Ye, Z.; Wang, X.; Xiao, L.*, Single-Particle Tracking with Scattering-Based Optical Microscopy. Anal. Chem. 2019, 91, 15327–15334. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b02760

7. Zhang, D.; Wei, L.; Zhong, M.; Xiao, L.*; Li, H.-W.; Wang, J., The Morphology and Surface Charge-Dependent Cellular Uptake Efficiency of Upconversion Nanostructures Revealed by Single-Particle Optical Microscopy. Chem. Sci. 2018, 9, 5260-5269. https://pubs.rsc.org/en/content/articlelanding/2018/SC/C8SC01828F#!divAbstract

6. Tan, H.; Huang, Y.; Xu, J.; Chen, B.; Zhang, P.; Ye, Z.; Liang, S.; Xiao, L.*; Liu, Z.*, Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy. Theranostics 2017, 7, 3168-3178. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566113/

5. Xiao, L.*; Yeung, E. S.*, Optical Imaging of Individual Plasmonic Nanoparticles in Biological Samples. Ann. Rev. Anal. Chem. 2014, 7, 89-111. https://www.annualreviews.org/doi/full/10.1146/annurev-anchem-071213-020125

4. Xiao, L.; Wei, L.; Liu, C.; He, Y.; Yeung, E. S.*, Unsynchronized Translational and Rotational Diffusion of Nanocargo on a Living Cell Membrane. Angew. Chem. Int. Ed. 2012, 51, 4181-4184. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201108647

3. Xiao, L.; Ha, J. W.; Wei, L.; Wang, G.; Fang, N.*, Determining the Full Three-Dimensional Orientation of Single Anisotropic Nanoparticles by Differential Interference Contrast Microscopy. Angew. Chem. Int. Ed. 2012, 51, 7734-7738. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201202340

2. Xiao, L.; Qiao, Y.; He, Y.*; Yeung, E. S., Imaging Translational and Rotational Diffusion of Single Anisotropic Nanoparticles with Planar Illumination Microscopy. J. Am. Chem. Soc. 2011, 133, 10638-10645. https://pubs.acs.org/doi/abs/10.1021/ja203289m

1. Xiao, L.; Zhao, D.; Chan, W.-H.; Choi, M. M. F.; Li, H.-W.*, Inhibition of Beta 1-40 Amyloid Fibrillation with N-acetyl-L-cysteine Capped Quantum Dots. Biomaterials 2010, 31, 91-98. https://www.sciencedirect.com/science/article/pii/S0142961209009302

***********************************Current***********************************

79. Ye, Z.; Yan, Z.-J.; Zhang, C.; Hou, J.-L.*; Yue, S.*; Xiao, L.*, Charged Tubular Supramolecule Boosting Multivalent Interactions for the Drastic Suppression of Aβ Fibrillation. Nano Lett. 2021, 21, 10494–10500. https://doi.org/10.1021/acs.nanolett.1c04007

78. Wang, T.; Wang, X.; Wang, H.; Li, L.; Zhang, C.; Xiang, R.; Tan, X.; Li, Z.; Jiang, C.; Zheng, L.; Xiao, L.*; Yue, S.*, High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced. J. Extracell. Vesicles 2021, 10, 12167.https://onlinelibrary.wiley.com/doi/full/10.1002/jev2.12167

77. Ma, Y.; Ye, Z.; Zhang, C.; Zhao, Y.*; Luo, H.*; Xiao, L.*, Curved carbon photo-oxygenation catalysts for the suppression and nanoscopic imaging of β-amyloid peptides fibrillation. Nano Res. 2021, DOI: 10.1007/s12274-021-3927-5. https://link.springer.com/article/10.1007/s12274-021-3927-5

76. Liu, H.; Geng, X.; Wang, X.; Wei, L.; Li, Z.; Lin, S.; Xiao, L.*, A Carbonized Fluorescent Nucleolus Probe Discloses RNA Reduction in the Process of Mitophagy. CCS Chemistry 2021, 3, 3081–3093. https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101371

75. Gen, W.-C.; Ye, Z.; Zheng, Z.; Gao, J.; Li, J.-J.; Shah, M. R.; Xiao, L.*; Guo, D.-S.* Supramolecular Bioimaging through Signal Amplification by Combining Indicator Displacement Assay with Förster Resonance Energy Transfer. Angew. Chem. Int. Ed. 2021, 60, 19766 –19771. https://doi.org/10.1002/anie.202104358

74. Wang, Xiao.; Ye, Z.; Hua, J.; Wei, L.; Lin, S.; Xiao, L.*, Fast Surface Restructuring within the Gap of Au Nanocube Dimer for the Enhancement of Catalytic Efficiency. CCS Chemistry 2021, 3, 1185-1197. https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202100770

73. Haoyang, W.-W.; Xiao, Q.; Ye, Z.; Fu, Y.; Zhang, D.-W.; Li, J.; Xiao, L.*; Li, Z.-T.*; Hou, J.-L.*, Gramicidin A-Based Unimolecular Channel: Cancer Cell-Targeting Behavior and Ion Transport-Induced Apoptosis, Chem. Commun. 2021, 57, 1097-1100. https://pubs.rsc.org/en/content/articlelanding/2021/CC/D0CC08073J#!divAbstract

72. Zhang, D.; Ye Z.; Liu, H.; Wang, X.; Hua, J.; Ling, Y.; Wei, L., Xia, Y.*, Sun, S.*, Xiao, L.*, Cell Membrane Coated Smart Two-Dimensional Supraparticle for in vivo Homotypic Cancer Targeting and Enhanced Combinational Theranostics. Nanotheranostics 2021, 5, 275-287. https://www.ntno.org/v05p0275.htm

71. Chen, D.; Song, Z.; Lian, M.; Yang, Y.; Lin, S.; Xiao, L.*, Single-Particle Fibrinogen Detection Using Platelet Membrane-Coated Fluorescent Polystyrene Nanoparticles. Nanoscale 2021, 13, 2914-2922. http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR08492A?page=search

***********************************2020***********************************

70. Ye, Z.; Geng, X.; Wei, L.; Li, Z.; Lin, S.; Xiao, L.*, Length Dependent Distinct Cytotoxic Effect of Amyloid Fibrils beyond Optical Diffraction Limit Revealed by Nanoscopic Imaging. ACS Nano 2021, 15, 934-943. https://pubs.acs.org/doi/abs/10.1021/acsnano.0c07555

69. Xu, Y.; Yang, Y.; Lin, S.; Xiao, L.*, Red-Emitting Carbon Nanodots-based Wide-Range Responsive Nanothermometer for Intracellular Temperature Sensing. Anal. Chem. 2020, 92, 15632-15638. https://pubs.acs.org/doi/10.1021/acs.analchem.0c03912

68. Chen, T.; Huang, M.; Ye, Z.; Hua, J.; Lin, S.*; Wei, L.*; Xiao, L.*, Blinking CsPbBr3 Perovskite Nanocrystals for the Nanoscopic Imaging of Electrospun Nanofibers. Nano Res. 2021, 14, 1397-1404. https://link.springer.com/article/10.1007/s12274-020-3189-7

67. Xu, J.; Wang, J.; Qiu, J.*; Liu, H.; Wang, Y.; Cui, Y.; Humphry, R.; Wang, N.; Durkan, C.; Chen, Y.; Lu, Y.; Ma, Q.; Wu, W.; Luo, Y.; Xiao, L.*; Wang, G.*, Nanoparticles Retard Immune Cells Recruitment in vivo by Inhibiting Chemokine Expression. Biomaterials 2021, 265, 120392. https://www.sciencedirect.com/science/article/pii/S0142961220306384

66. Yan, Z.; Wang, D.; Ye, Z.; Fan, T.; Wu, G.; Deng, L.; Yang, L.; Li, B.; Liu, J.; Ma, T.; Dong, C.; Li, Z.; Xiao, L.*; Wang, Y.*; Wang, W.*; Hou, J.*, Artificial Aquaporin That Restores Wound Healing of Impaired Cells. J. Am. Chem. Soc. 2020, 142, 15638–15643. https://pubs.acs.org/doi/10.1021/jacs.0c00601

65. Ma, Y.; Ye, Z.; Zhang, C.; Wang, X.; Li, H.; Wang, M. S.; Luo, H.*; Xiao, L.*, Deep Red Blinking Fluorophore for Nanoscopic Imaging and Inhibition of β-Amyloid Peptide Fibrillation. ACS Nano 2020, 14, 11341–11351. https://pubs.acs.org/doi/10.1021/acsnano.0c03400

64. Xu, Y.; Xiao, L.*, Efficient Suppression of Amyloid-β Peptide Aggregation and Cytotoxicity with Photosensitive Polymer Nanodots. J. Mater. Chem. B. 2020, 8, 5776-5782. https://doi.org/10.1039/D0TB00302F

63. Qi, F.; Han, Y.; Liu H.; Meng H.; Li, Z.*; Xiao, L.*, Localized Surface Plasmon Resonance Coupled Single-Particle Galactose Assay with Dark-Field Optical Microscopy. Sensor. Actuat. B Chem. 2020, 320, 128347. https://www.ntno.org/v05p0275.htmhttps://www.sciencedirect.com/science/article/pii/S0925400520306924

62. Tian, M.; Yuan, Z.*; Liu, Y.; Lu, C.; Ye, Z.; Xiao, L.*, Recent Advances of Plasmonic Nanoparticle-Based Optical Analysis in Homogeneous Solution and at the Single-Nanoparticle Level. Analyst 2020, 145, 4737-4752. https://pubs.rsc.org/en/content/articlepdf/2020/an/d0an00609b

61. Liu, H.; Wei, L.; Hua, J.; Chen, D.; Meng, H.; Li, Z.*; Xiao, L.*, Enzyme Activity-Modulated Etching of Gold Nanobipyramids@MnO₂ Nanoparticles for ALP Assay with Surface-Enhanced Raman Spectroscopy. Nanoscale 2020, 12, 10390-10398. https://pubs.rsc.org/en/content/articlelanding/2020/nr/d0nr01837f#!divAbstract

60. Guo, X.; Lu, D.; Zhang, D.; Deng, J.; Zhang, X.; Wang, Z.*; Xiao, L.*; Zhao, Y.*, Curved Corannulene Dually Targets Mitochondria and Endoplasmic Reticulum, and Initiates Apotosis via Localized ROS Induction upon Light Triggering. Mater. Sci. Eng. C 2020, 106, 110227. https://www.sciencedirect.com/science/article/pii/S0928493119320995

59. Han, Y.; Ye, Z.; Chen, L.; Xiao, L.*, Gold Nanoparticles Enumeration with Dark-Field Optical Microscope for the Sensitive Glycoprotein Sandwich Assay. Anal. Chim. Acta 2020, 1109, 53-60. https://www.sciencedirect.com/science/article/pii/S0003267020303044

***********************************2019***********************************

58. Ye, Z.; Wei, L.; Geng, X.; Wang, X.; Li, Z.; Xiao, L.*, Mitochondrion-Specific Blinking Fluorescent Bioprobe for Nanoscopic Monitoring of Mitophagy. ACS Nano 2019, 13, 11593-11602. https://pubs.acs.org/doi/10.1021/acsnano.9b05354

57. Ye, Z.; Wang, X.; Xiao, L.*, Single-Particle Tracking with Scattering-Based Optical Microscopy. Anal. Chem. 2019, 91, 15327-15334. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b02760

56. Zhang, D.; Ye, Z.; Wei, L.*; Luo, H.*; Xiao, L.*, Cell Membrane-Coated Porphyrin Metal-Organic Frameworks for Cancer Cell Targeting and O2-Evolving Photodynamic Therapy. ACS Appl. Mater. Interfaces 2019, 11, 39594-39602. https://pubs.acs.org/doi/abs/10.1021/acsami.9b14084

55. Wang, S.; Ye, Z.; Wang, X.; Xiao, L.*, Etching of Single MnO2-Coated Gold Nanoparticles for the Colorimetric Detection of Organophosphorus Pesticides. ACS Appl. Nano Mater. 2019, 2, 6646-6654. https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01517

54. Wang, F.; Han, Y.; Wang, S.; Ye, Z.; Wei, L.*; Xiao, L.*, Single-Particle LRET Aptasensor for the Sensitive Detection of Aflatoxin B1 with Upconversion Nanoparticles. Anal. Chem. 2019, 91, 11856-11863. https://pubs.acs.org/doi/10.1021/acs.analchem.9b02599

53. Han, Y.; Chen T.; Li, Y.; Chen, L.; Wei, L.; Xiao, L.*, Single-Particle Enumeration-Based Sensitive Glutathione S-Transferase Assay with Fluorescent Conjugated Polymer Nanoparticles. Anal. Chem. 2019, 91, 11146-11153. https://doi.org/10.1021/acs.analchem.9b01849

52. Han, Y.; Ye, Z.; Wang, F.; Chen, T.; Wei, L.; Chen, L.*; Xiao, L.*, Single-Particle Enumeration-Based Ultrasensitive Enzyme Activity Quantification with Fluorescent Polymer Nanoparticles. Nanoscale 2019, 11, 14793-14801. https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr01817d#!divAbstract

51. Ye, Z.; Wei, L.; Li, Y.; Xiao, L.*, Efficient Modulation of β-Amyloid Peptide Fibrillation with Polymer Nanoparticles Revealed by Super-Resolution Optical Microscopy. Anal. Chem. 2019, 91, 8582-8590. https://pubs.acs.org/doi/10.1021/acs.analchem.9b01877

50. Ling, Y.; Zhang, D.; Cui, X.; Wei, M.; Zhang, T.; Wang, J.; Xiao, L.*; Xia, Y.*, Direct Monitoring Cell Membrane Vesiculation with 2D AuNP@MnO2 Nanosheet Supraparticles at Single-Particle Level. Angew. Chem. Int. Ed. 2019, 58, 10542-10546. https://doi.org/10.1002/anie.201902987

49. He, L.; Li, Y.; Wei, L.; Ye, Z.; Liu, H.; Xiao, L.*, Correlation between Translational and Rotational Diffusion of Rod-Shaped Nanocargo on Lipid Membrane Revealed by Single-Particle Tracking. Nanoscale 2019, 11, 10080-10087. https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr01964b#!divAbstract

48. Ye, Z.; Wei, L.; Xiao, L.*; Wang, J., Laser Illumination-Induced Dramatic Catalytic Activity Change on Au Nanospheres. Chem. Sci. 2019, 10, 5793-5800. https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc01666j#!divAbstract

47. Wang, F., Li, Y.; Han, Y.; Ye, Z.; Wei, L.; Xiao, L.*, Single-Particle Enzyme Activity Assay with Spectral-Resolved Dark-Field Optical Microscopy. Anal. Chem. 2019, 91, 6329-6339. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b01300

46. Xu, Y.; Li, Y.; Wei, L.; Liu, H.; Qiu, J.; Xiao, L.*, Attenuation of the Aggregation and Neurotoxicity of Amyloid Peptides with Neurotransmitter-Functionalized Ultra-Small-Sized Gold Nanoparticles. Eng. Sci. 2019, 6, 53-63. http://www.espublisher.com/journals/articledetails/54/

45. Ye, Z.; Liu, H.; Wang, F.; Wang, X.; Wei, L.; Xiao, L.*, Single-Particle Tracking Discloses Binding-Mediated Rocking Diffusion of Rod-Shaped Biological Particles on Lipid Membranes. Chem. Sci. 2019, 10, 1351-1359. https://pubs.rsc.org/en/content/articlelanding/2019/SC/C8SC04033H#!divAbstract

44. Ma, Y.; Wang, X.; Liu, H.; Wei, L.; Xiao, L.*, Recent Advances in Optical Microscopic Methods for Single-Particle Tracking in Biological Samples. Anal. Bioanal. Chem. 2019, 411, 4445–4463. https://link.springer.com/article/10.1007/s00216-019-01638-z

43. Liu, H.; Ye, Z.; Wang, X.; Wei, L.; Xiao, L.*, Molecular and Living Cell Dynamic Assays with Optical Microscopy Imaging Techniques. Analyst 2019, 144, 859-871. https://pubs.rsc.org/en/content/articlelanding/2019/AN/C8AN01420E#!divAbstract

***********************************2018***********************************

42. Ye, Z.; Liu H.; Xiao L.*, Recent Advances of Single Molecule/Particle Imaging with Optical Microscopic Methods. Sci. Sin. Chem. 2018, 49, 787-800. (Review, 庆祝南开大学成立100周年专刊) http://engine.scichina.com/publisher/scp/journal/SSC/49/5/10.1360/N032018-00199?slug=fulltext

41. Zhang, P.; Wang, H.; Zhang, D.; Zeng, X.; Zeng, R.*; Xiao, L.*; Tao, H.; Long, Y.; Yi, P.; Chen, J.*, Two-photon Fluorescent Probe for Lysosome-Targetable Hypochlorous Acid Detection within Living Cells. Sens. Actuators B Chem. 2018, 255, 2223-2231. https://www.sciencedirect.com/science/article/pii/S0925400517316787

40. Zhang, D.; Wei, L.; Zhong, M.; Xiao, L.*; Li, H.-W.; Wang, J., The Morphology and Surface Charge-Dependent Cellular Uptake Efficiency of Upconversion Nanostructures Revealed by Single-Particle Optical Microscopy. Chem. Sci. 2018, 9, 5260-5269. https://pubs.rsc.org/en/content/articlelanding/2018/SC/C8SC01828F#!divAbstract

39. Yu, Y.; Ma, L.; Li, L.; Deng, Y.; Xu, L.; Liu, H.; Xiao, L.*; Su, X.*, Digestion of Dynamic Substrate by Exonuclease Reveals High Single-Mismatch Selectivity. Anal. Chem. 2018, 90, 13655-13662. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b03963

38. Ye, Z.; Weng, R.; Ma, Y.; Wang, F.; Liu, H.; Wei, L.*; Xiao, L.*, Label-Free Single-Particle Colorimetric Detection of Permanganate by GNPs@Ag Core-Shell Nanoparticles with Dark-Field Optical Microscopy. Anal. Chem. 2018, 90, 13044-13050. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b04024

37. Ye, Z.; Wei, L.; Zeng, X.; Weng, R.; Shi, X.; Wang, N.; Chen, L.; Xiao, L.*, Background-Free Imaging of a Viral Capsid Proteins Coated Anisotropic Nanoparticle on a Living Cell Membrane with Dark-Field Optical Microscopy. Anal. Chem. 2018, 90, 1177-1185. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b03762

36. Wei, L.; Zhang, D.; Zheng, X.; Zeng, X.; Zeng, Y.; Shi, X.; Su, X.; Xiao, L.*, Fabrication of Positively Charged Fluorescent Polymer Nanoparticles for Cell Imaging and Gene Delivery. Nanotheranostics 2018, 2, 157-167. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865269/

35. Shi, X.*; He, Y.; Gao, W.; Liu, X.; Ye, Z.; Liu, H.; Xiao, L.*, Quantifying the Degree of Aggregation from Fluorescent Dye-Conjugated DNA Probe by Single Molecule Photobleaching Technology for the Ultrasensitive Detection of Adenosine. Anal. Chem. 2018, 90, 3661-3665. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b05317

34. Qi, F.; Han, Y.; Ye, Z.; Liu, H.; Wei, L.; Xiao, L.*, Color-Coded Single-Particle Pyrophosphate Assay with Dark-Field Optical Microscopy. Anal. Chem. 2018, 90, 11146-11153. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b03211

33. Pan, A.; Zhong, M.; Wu, H.; Peng, Y.; Xia, H.; Tang, Q.; Huang, Q.; Wei, L.; Xiao, L.*; Peng, C.*, Topical Application of Keratinocyte Growth Factor Conjugated Gold Nanoparticles Accelerate Wound Healing. Nanomedicine: NBM 2018, 14, 1619-1628. https://www.sciencedirect.com/science/article/pii/S1549963418300790

32. Li, X.; Wei, L.; Pan, L.; Yi, Z.; Wang, X.; Ye, Z.; Xiao, L.*; Li, H.-W.*; Wang, J., Homogeneous Immunosorbent Assay Based on Single-Particle Enumeration Using Upconversion Nanoparticles for the Sensitive Detection of Cancer Biomarkers. Anal. Chem. 2018, 90, 4807-4814. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b00251

***********************************2017***********************************

31. Zhang, Z.; Zhang, D.; Wei, L.; Wang, X.; Xu, Y.; Li, H.-W.; Ma, M.*; Chen, B.; Xiao, L.*, Temperature Responsive Fluorescent Polymer Nanoparticles (TRFNPs) for Cellular Imaging and Controlled Releasing of Drug to Living Cells. Colloid. Surface. B. 2017, 159, 905-912. https://www.sciencedirect.com/science/article/pii/S0927776517305611

30. Wei, L.; Ma, Y.; Zhu, X.; Xu, J.; Wang, Y.; Duan, H.; Xiao, L.*, Sub-Diffraction-Limit Localization Imaging of a Plasmonic Nanoparticle Pair with Wavelength Resolved Dark-Field Microscopy. Nanoscale 2017, 9, 8747-8755. https://pubs.rsc.org/en/content/articlelanding/2017/NR/C7NR02474F#!divAbstract

29. Wei, L.; Ma, Y.; Shi, X.; Wang, Y.; Su, X.; Yu, C.; Xiang, S.; Xiao, L.*; Chen, B.*, Living Cell Intracellular Temperature Imaging with Biocompatible Dye-Conjugated Carbon Dots. J. Mater. Chem. B 2017, 5, 3383-3390. https://pubs.rsc.org/en/content/articlelanding/2017/TB/C7TB00309A#!divAbstract

28. Tan, H.; Huang, Y.; Xu, J.; Chen, B.; Zhang, P.; Ye, Z.; Liang, S.; Xiao, L.*; Liu, Z.*, Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy. Theranostics 2017, 7, 3168-3178. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566113/

27. Su, X.; Li, Z.; Yan, X.; Wang, L.; Zhou, X.; Wei, L.; Xiao, L.*; Yu, C.*, Telomerase Activity Detection with Amplification-Free Single Molecule Stochastic Binding Assay. Anal. Chem. 2017, 89, 3576-3582. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b04883

26. Song, W.; Duan, W.; Liu, Y.; Ye, Z.; Chen, Y.; Chen, H.; Qi, S.; Wu, J.; Liu, D.; Xiao, L.*; Ren, C.*; Chen, X., Ratiometric Detection of Intracellular Lysine and pH with One-Pot Synthesized Dual Emissive Carbon Dots. Anal. Chem. 2017, 89, 13626-13633. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b04211

***********************************2016***********************************

25. Yang, Q.; Ye, Z.; Zhong, M.; Chen, B.; Chen, J.; Zeng, R.; Wei, L.*; Li, H.-W.*; Xiao, L.*, Self-Assembled Fluorescent Bovine Serum Albumin Nanoprobes for Ratiometric pH Measurement inside Living Cells. ACS Appl. Mater. Interfaces 2016, 8, 9629-9634. https://pubs.acs.org/doi/abs/10.1021/acsami.6b00857

24. Wei, L.; Ye, Z.; Xu, Y.; Chen, B.; Yeung, E. S.; Xiao, L.*, Single Particle Tracking of Peptides-Modified Nanocargo on Lipid Membrane Revealing Bulk-Mediated Diffusion. Anal. Chem. 2016, 88, 11973-11977. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03420

23. Wei, L.; Ye, Z.; Luo, W.; Chen, B.; Xiao, L.*, Redistribution of Fluorescent Molecules at the Solid/Liquid Interface with Total Internal Reflection Illumination. Talanta 2016, 155, 229-234. https://www.sciencedirect.com/science/article/pii/S0039914016302600

22. Wei, L.; Xu, J.; Ye, Z.; Zhu, X.; Zhong, M.; Luo, W.; Chen, B.; Duan, H.; Liu, Q.; Xiao, L.*, Orientational Imaging of a Single Gold Nanorod at the Liquid/Solid Interface with Polarized Evanescent Field Illumination. Anal. Chem. 2016, 88, 1995-1999. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.5b04695

21. Tan, H.; Luo, W.; Wei, L.; Chen, B.; Li, W.; Xiao, L.*; Manzhos, S.*; Liu, Z.*; Liang, S., Quantifying the Distribution of the Stoichiometric Composition of Anticancer Peptide Lycosin-I on the Lipid Membrane with Single Molecule Spectroscopy. J. Phys. Chem. B 2016, 120, 3081-3088. https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.5b12618

20. Poon, C.-Y.; Wei, L.; Xu, Y.; Chen, B.; Xiao, L.*; Li, H.-W.*, Quantification of Cancer Biomarkers in Serum Using Scattering-Based Quantitative Single Particle Intensity Measurement with a Dark-Field Microscope. Anal. Chem. 2016, 88, 8849-8856. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b02429

19. Ma, Y.; Zhang, Z.; Xu, Y.; Ma, M.; Chen, B.; Wei, L.*; Xiao, L.*, A Bright Carbon-Dot-Based Fluorescent Probe for Selective and Sensitive Detection of Mercury Ions. Talanta 2016, 161, 476-481. https://www.sciencedirect.com/science/article/pii/S0039914016306671

18. Luo, W.; Wu, M.; Li, S.; Xu, Y.; Ye, Z.; Wei, L.; Chen, B.; Xu, Q.-H.; Xiao, L.*, Nanoprecipitation of Fluorescent Conjugated Polymer onto the Surface of Plasmonic Nanoparticle for Fluorescence/Dark-Field Dual-Modality Single Particle Imaging. Anal. Chem. 2016, 88, 6827-6835. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b01350

***********************************2015***********************************

17. Yang, Q.; Wei, L.; Zheng, X.; Xiao, L.*, Single Particle Dynamic Imaging and Fe³⁺ Sensing with Bright Carbon Dots Derived from Bovine Serum Albumin Proteins. Sci. Rep. 2015, 5, 17727. https://www.nature.com/articles/srep17727

***********************************2014***********************************

16. Xiao, L.*; Yeung, E. S.*, Optical Imaging of Individual Plasmonic Nanoparticles in Biological Samples. Ann. Rev. Anal. Chem. 2014, 7, 89-111. https://www.annualreviews.org/doi/full/10.1146/annurev-anchem-071213-020125

15. Wei, L.; Zhou, P.; Yang, Q.; Yang, Q.; Ma, M.; Chen, B.; Xiao, L.*, Fabrication of Bright and Small Size Semiconducting Polymer Nanoparticles for Cellular Labelling and Single Particle Tracking. Nanoscale 2014, 6, 11351-11358. https://pubs.rsc.org/en/content/articlelanding/2014/NR/C4NR03293D

14. Wei, L.; Yang, Q.; Xiao, L.*, Tempo-Spatially Resolved Cellular Dynamics of Human Immunodeficiency Virus Transacting Activator of Transcription (Tat) Peptide-Modified Nanocargos in Living Cells. Nanoscale 2014, 6, 10207-10215. https://pubs.rsc.org/en/content/articlelanding/2014/NR/C4NR02732A#!divAbstract

13. Li, H.; Guo, Y.; Xiao, L.*; Chen, B.*, Selective and Sensitive Detection of Acetylcholinesterase Activity Using Denatured Protein-Protected Gold Nanoclusters as a Label-Free Probe. Analyst 2014, 139, 285-289. https://pubs.rsc.org/en/content/articlelanding/2014/AN/C3AN01736B#!divAbstract

12. Li, H.; Guo, Y.; Xiao, L.*; Chen, B.*, A Fluorometric Biosensor Based on H2O2-Sensitive Nanoclusters for the Detection of Acetylcholine. Biosens. Bioelectron. 2014, 59, 289-292. https://www.sciencedirect.com/science/article/pii/S0956566314002358

***********************************2013***********************************

11. Wei, L.; Zhao, X.; Chen, B.; Li, H.; Xiao, L.*; Yeung, E. S.*, Frozen Translational and Rotational Motion of Human Immunodeficiency Virus Transacting Activator of Transcription Peptide-Modified Nanocargo on Neutral Lipid Bilayer. Anal. Chem. 2013, 85, 5169-5175. https://pubs.acs.org/doi/abs/10.1021/ac400503z

10. Wei, L.; Liu, C.; Chen, B.; Zhou, P.; Li, H.; Xiao, L.*; Yeung, E. S.*, Probing Single-Molecule Fluorescence Spectral Modulation within Individual Hotspots with Subdiffraction-Limit Image Resolution. Anal. Chem. 2013, 85, 3789-3793. https://pubs.acs.org/doi/abs/10.1021/ac400240v

+++++++++++++++++++++++++Independent Work+++++++++++++++++++++++++++

***********************************2012***********************************

9. Xiao, L.; Wei, L.; Liu, C.; He, Y.; Yeung, E. S.*, Unsynchronized Translational and Rotational Diffusion of Nanocargo on a Living Cell Membrane. Angew. Chem. Int. Ed. 2012, 51, 4181-4184. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201108647

8. Xiao, L.; Ha, J. W.; Wei, L.; Wang, G.; Fang, N.*, Determining the Full Three-Dimensional Orientation of Single Anisotropic Nanoparticles by Differential Interference Contrast Microscopy. Angew. Chem. Int. Ed. 2012, 51, 7734-7738. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201202340

***********************************2011***********************************

7. Xiao, L.; Wei, L.; Cheng, X.; He, Y.*; Yeung, E. S., Noise-Free Dual-Wavelength Difference Imaging of Plasmonic Resonant Nanoparticles in Living Cells. Anal. Chem. 2011, 83, 7340-7347. https://pubs.acs.org/doi/abs/10.1021/ac2012366

6. Xiao, L.; Qiao, Y.; He, Y.*; Yeung, E. S., Imaging Translational and Rotational Diffusion of Single Anisotropic Nanoparticles with Planar Illumination Microscopy. J. Am. Chem. Soc. 2011, 133, 10638-10645. https://pubs.acs.org/doi/abs/10.1021/ja203289m

***********************************2010***********************************

5. Xiao, L.; Zhao, D.; Chan, W.-H.; Choi, M. M. F.; Li, H.-W.*, Inhibition of Beta 1-40 Amyloid Fibrillation with N-acetyl-L-cysteine Capped Quantum Dots. Biomaterials 2010, 31, 91-98. https://www.sciencedirect.com/science/article/pii/S0142961209009302

4. Xiao, L.; Wei, L.; He, Y.*; Yeung, E. S., Single Molecule Biosensing Using Color Coded Plasmon Resonant Metal Nanoparticles. Anal. Chem. 2010, 82, 6308-6314. https://pubs.acs.org/doi/abs/10.1021/ac101018v

3. Xiao, L.; Qiao, Y.; He, Y.*; Yeung, E. S.*, Three Dimensional Orientational Imaging of Nanoparticles with Darkfield Microscopy. Anal. Chem. 2010, 82, 5268-5274. https://pubs.acs.org/doi/abs/10.1021/ac1006848

***********************************2009***********************************

2. Xiao, L.; Zhou, R.; He, Y.*; Li, Y.; Yeung, E. S.*, Direct Observation of Nanoparticle Self-Assembly Dynamics at the Water-Air Interface Using Differential Interference Contrast Microscopy. J. Phys. Chem. C 2009, 113, 1209-1216. https://pubs.acs.org/doi/abs/10.1021/jp807776w

1. Xiao, L.; He, Y.*; Yeung, E. S.*, High Throughput Single Molecule Spectral Imaging of Photoactivated Luminescent Silver Clusters on Silver Island Films. J. Phys. Chem. C 2009, 113, 5991-5997. https://pubs.acs.org/doi/abs/10.1021/jp8102904