Prof. Dr. Lehui Xiao (肖乐辉 教授)
ADDRESS
State Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin, 300071, China
E-mail: lehuixiao@nankai.edu.cn
WORKING EXPERIENCE
Investigator Nankai University, Nankai, Tianjin, China 2016.04-now
Full Professor Hunan Normal University, Changsha, Hunan, China 2013.01-2016-03
Assistant Professor Hunan Normal University, Changsha, Hunan, China 2012.09-2013.01
Postdoc. Research University of Washington, Seattle, WA, U.S.A. 2011.12-2012.09
Postdoc. Research Ames Lab., DOE, Ames, Iowa, U.S.A. 2011.09-2011.12
EDUCATION
Ph. D. Hunan University & Iowa State University 2008-2011 Analytical Chemistry
M. S. Hunan University & HongKong Baptist University 2006-2008 Analytical Chemistry
B. S. Hunan University 2002-2006 Chemistry
HONORS & AWARDS
Henry Fok Young Teachers Award 2016 China
The National Science Fund for Excellent Young Scholars 2015 China
Program for New Century Excellent Talents in University 2014 China
The Hunan Province Science Fund for Distinguished Young Scholars 2014 Hunan Province
Award for Excellent Doctoral Student Granted by Ministry of Education 2010 China
Excellent Graduate Student 2010 Hunan University
Excellent Student 2005 Hunan University
2nd –Class Scholarship 2005 Hunan University
National Scholarship 2004 China
Triple A Student 2004 Hunan University
1st –Class Scholarship 2004 Hunan University
National Scholarship 2003 China
Triple A Student 2003 Hunan University
1st –Class Scholarship 2003 Hunan University
肖乐辉，男，南开大学化学学院特聘研究员，博士生导师。2002-2011年在湖南大学分析化学专业获学士-硕士-博士学位，于2008年赴香港浸会大学进行访问研究一年。2011-2012年分别在美国能源部 Ames 实验室以及华盛顿大学进行博士后研究。2012-2015年受聘为湖南师范大学潇湘学者特聘教授。国家自然科学基金委基金评审专家，J. Am. Chem. Soc., Anal. Chem., Chem. Com.等国际学术期刊审稿专家，湖南省省委党校22期中青年专家班学员，湖南省海外留学青年联谊会会员，湖南省科协委员。目前主要从事功能纳米材料的制备及其光物理化学等性能的分析，单分子及单颗粒光谱分析以及单细胞成像分析。曾作为核心成员参与完成多项自然科学基金面上课题。目前主持国家自然科学基金优秀青年科学基金一项，国家自然科学基金青年项目一项，湖南省杰出青年科学基金一项，教育部新世纪优秀人才支持计划一项，曾获教育部博士学术新人奖，霍英东青年教师奖（2016年度），于2014年获选为湖南省创新创业青年培养对象。
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Collaborators
Dr. Lin Wei
Associate Professor
College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China
Email:happywei2012@126.com
https://hgxy.hunnu.edu.cn/teacherShow.asp?class_id=147&pro_id=133
魏琳，女，于2012年6月，在湖南大学分析化学专业获博士学位，师从国际著名分析化学家Edward S. Yeung教授。在此期间，作为主要研究成员参与完成“实时单分子光谱分析及其在功能纳米材料研究中的应用”、“功能化金纳米颗粒的实时单分子光谱分析及其在生物医学研究中的应用”、“基于实时单分子光谱技术的纳米颗粒早期自组装过程研究”等多项自然科学基金课题，并于2010-2012年在美国Iowa State University和能源部下属Ames实验室访问研究两年。2013年10月，受聘于湖南师范大学，在2015年破格晋至副教授职称。获得国家自然科学基金委青年基金项目一项，湖南省教育厅优秀青年基金项目一项。长期从事贵金属纳米材料的制备和修饰，光学显微成像方法的开发与应用工作。相关研究成果均发表在Anal.Chem., Nanoscale, ACS Appl. Mater. Interfaces, J. Phys. Chem. B, Talanta等国际著名杂志上。
代表论文：
1. Wei, L.; Zheng, X.; Ye, Z.; Xu, Y.; Zhang, D.; Xiao, L.* Positively Charged Small Size Fluorescent Conjugated Polymer Dots for Gene Delivery and Intracellular Imaging. Nanotheranostics, 2018, 2, 157-167.
2. L.Wei, Y. Ma, X. Shi, Y. Wang, X. Su, C. Yu, S. Xiang, L. Xiao* and B. Chen*. Living cell intracellular temperature imaging with biocompatible dye-conjugated carbon dots. J. Mater. Chem. B, 2017, 5, 3383-3390.
3. L. Wei, Y. Ma, X. Zhu, J. Xu, Y. Wang, H. Duan and L. Xiao*.Sub-diffraction-limit localization imaging of a plasmonic nanoparticle pair with wavelength-resolved dark-field microscopy. Nanoscale, 2017, 9, 8747-8755.
4. L. Wei, Z. Ye, Y. Xu, B. Chen, E. Yeung and L. Xiao*. Single Particle Tracking of Peptide-Modified Nanocargo on Lipid Membrane Reveals Bulk-Mediated Diffusion. Anal. Chem., 2016, 88(24), 11973-11977.
5. L. Wei, J. Xu, Z. Ye, X. Zhu, M. Zhong, W. Luo, B. Chen, H. Duan, Q. Liu and L. Xiao*, Orientational Imaging of a Single Gold Nanorod at the Liquid/Solid Interface with Polarized Evanescent Field Illumination. Anal. Chem., 2016, 88(4), 1995-1999.
6. Q.Yang, Z. Ye, M. Zhong, B. Chen, J. Chen, R. Zeng, L. Wei*, H. Li* and L. Xiao*, Self-assembled Fluorescent Bovine Serum Albumin Nanoprobes for Ratiometric pH Measurement inside Living Cells. ACS Appl. Mater. Interfaces, 2016, 8(15), 9629-9634.
7. L. Wei, P. Zhou, Q. Yang, Q. Yang, M. Ma, B. Chen and L. Xiao*. Fabrication of Bright and Small Size Semiconducting Polymer Nanoparticles for Cellular Labelling and Single Particle Tracking. Nanoscale, 2014, 6, 11351-11358.
8. L. Wei, Q. Yang, and L. Xiao*. Tempo-spatially Resolved Cellular Dynamics of Human Immunodeficiency Virus Transacting Activator of Transcription (Tat) Peptide-modified Nanocargos in Living Cells. Nanoscale, 2014, 6, 10207-10215.
9. L. Wei, X. Zhao, B. Chen, H. Li, L. Xiao* and E. S. Yeung*. Frozen Translational and Rotational Motion of Human Immunodeficiency Virus Transacting Activator of Transcription Peptide-Modified Nanocargo on Neutral Lipid Bilayer. Anal. Chem., 2013, 85, 5169–5175.
10. L. Wei, C. Liu, B. Chen, P. Zhou, H. Li, L. Xiao* and E. S. Yeung*. Probing Single-Molecule Fluorescence Spectral Modulation within Individual Hotspots with Subdiffraction-Limit Image Resolution. Anal. Chem., 2013, 85, 3789-3793.
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PhD Students
************2019************
Yi Yang (杨毅)
B.S. Jiangsu University
M.S. Nanjing University
Research Direction: Single-molecule imaging and single-particle tracking
1. Yang, Y.; Xue, L.; Zheng, J.; Li, C.; Huang, Y.; Xiang, Y.; Wang, ZX; Li, GX.* Erythrocyte membrane-biointerfaced spherical nucleic acids: Robust performance for microRNA quantification. Anal. Chim. Acta 2019, 1080, 189-195.
2. Yang, Y.; Li, C.; Shi, H.; Chen, TS.; Wang, ZX; Li, GX.* A pH-responsive bioassay for paper-based diagnosis of exosomes via mussel-inspired surface chemistry. Talanta 2019, 192, 325-330.
3. Li, C.; Tao, YQ.; Yang, Y.; Chen, TS.; Xiang, Y; Li, GX.* In Vitro Analysis of DNA-Protein Interactions in Gene Transcription Using DNAzyme-Based Electrochemical Assay. Anal. Chem. 2017, 89, 5003-5007.
4. Li, C.; Tao, YQ.; Yang, Y.; Chen, TS.; Feng, C.; Xiang, Y; Li, GX.* Dynamic sandwich-type electrochemical assay for protein quantification and protein-protein interaction. Analyst 2017, 142, 4399-4404.
Jianhao Hua （华建豪）
B.S. Fuzhou University
Research Direction: Catalysis
1. Hua, J.; Jiao, Y.; Wang, M.; Yang, Y.* Determination of norfloxacin or ciprofloxacin by carbon dots fluorescence enhancement using magnetic nanoparticles as adsorbent. Microchim Acta 2018, 185(2), 137.
2. Hua, J.; Wang, M.; Jiao, Y.; Li, H.; Yang, Y.* Strongly coupled CdX (X=S, Se and Te) quantum dots/TiO2 nanocomposites for photocatalytic degradation of benzene under visible light irradiation. Optik 2018, 171, 95-106.
3. Hua, J.; Yang, J.; Zhu, Y.; Zhao, C.; Yang, Y.* Highly fluorescent carbon quantum dots as nanoprobes for sensitive and selective determination of mercury (II) in surface waters. Spectrochim Acta A 2017, 187, 149-155.
4. Wang, M.‡; Hua, J.‡; Yang, Y.* Fabrication of CDs/CdS-TiO2 ternary nanocomposites for photocatalytic degradation of benzene and toluene under visible light irradiation. Spectrochim Acta A 2018, 199, 102-109.
************2018************
Hua Liu (刘华)
B.S. Taiyuan University of Technology
M.S. Jilin University
Research Direction: Single particle tracking and detection
1. Liu, H.; Wei, L.; Hua, J.; Chen, D.; Meng, H.; Li, Z.*; Xiao, L.*, Enzyme activity-modulated etching of gold nanobipyramids@MnO2 nanoparticles for ALP assay with surface-enhanced Raman spectroscopy. Nanoscale, 2020, 12, 10390-10398.
2. Liu, H.; Ye, Z.; Wang, X.; Wei, L.; Xiao, L.* Molecular and Living Cell Dynamic Assay with Optical Microscopic Imaging Techniques. Analyst 2019, 144, 859-871.
3. Liu H., Li N., Zhang H., Zhang F., Su X.* A simple and convenient fluorescent strategy for the highly sensitive detection of dopamine and ascorbic acid based on graphene quantum dots. Talanta 2018, 189, 190-195.2
4. Liu H., Li X., Wang M., Chen X., Su X.* A redox-modulated fluorescent strategy for the highly sensitive detection of metabolites by using graphene quantum dots. Anal. Chim. Acta 2017, 990, 150-156.
5. Liu H., Na W., Liu Z., Chen X., Su X.* A novel turn-on fluorescent strategy for sensing ascorbic acid using graphene quantum dots as fluorescent probe. Biosens. Bioelectron. 2017, 92, 229-233.
6. Ye, Z.; Liu, H.; Wang, F.; Wang, X.; Wei, L.; Xiao, L.* Single-Particle Tracking Discloses Binding-Mediated Rocking Diffusion of Rod-Shaped Biological Particle on Lipid Membrane. Chem. Sci. 2018, 10, 1351-1359.
7. Liu Z., Liu H., Liu L., Su X.* Aptamer based lysozyme assay using fluorescent CuInS2 quantum dots and graphene oxide, and its application to inhibitor screening. Microchim. Acta 2016, 183(11), 2907-2916.
8. Na W., Liu H., Wang M., Su X.* A boronic acid based glucose assay based on the suppression of the inner filter effect of gold nanoparticles on the orange fluorescence of graphene oxide quantum dots. Microchim. Acta 2017, 184(5), 1463-1470.
Xin Wang （王鑫）
B.S. Jilin University
M.S. Jilin University
Research Direction: Single molecule detection and single cell imaging
1. Ye, Z.‡; Wang, X.‡; Xiao, L.*, Single-Particle Tracking with Scattering-based Optical Microscopy. Anal. Chem. 2019, 91, 15327-15334.
2. Wang, X.; Liu, Z.-J.; Hill, E. H.; Zheng, Y.; Guo, G.; Wang, Y.; Weiss, P. S.; Yu, J.; Yang, Y.-W.* Organic-Inorganic Hybrid Pillarene-Based Nanomaterial for Label-Free Detection and Catalysis. Matter 2019, DOI: 10.1016/j.matt.2019.03.005
3. Wang, X.; Wu, J.-R.; Liang, F.; and Yang, Y.-W.* In Situ Gold Nanoparticle Synthesis Mediated by a Water-Soluble Leaning Pillar[6]arene for Self-Assembly, Detection, and Catalysis. Org. Lett. 2019, 21, 5215-5218.
4. Wang, X.; Tan, L.-L.; Li, X.; Song, N.; Li, Z.; Hu, J.-N.; Cheng, Y.-M.; Wang, Y.; Yang, Y.-W.* Smart Mesoporous Silica Nanoparticles Gated by Pillararene-Modified Gold Nanoparticles for On-Demand Cargo Release. Chem. Commun. 2016, 52, 13775–13778.
5. Wang, X.; Tan, L.-L.; Yang, Y.-W.* Controlled Drug Release Systems Based on Mesoporous Silica Capped by Gold Nanoparticles. Acta Chim. Sinica 2016, 74, 303–311.
6. Wu, M.-X.; Wang, X.; Yang, Y.-W. * Polymer Nanoassembly as Delivery Systems and Anti-Bacterial Toolbox: From PGMAs to MSN@PGMAs. Chem. Rec. 2017, DOI: 10.1002/tcr.201700036.
7. Zhou, H.; Wang, X.; Tang, J.;* Yang, Y.-W.* Surface Immobilization of pH-Responsive Polymer Brushes on Mesoporous Silica Nanoparticles by Enzyme Mimetic Catalytic ATRP for Controlled Cargo Release. Polymers 2016, 8, 277. IF: 3.364. DOI: 10.3390/polym8080277.
8. Zhou, H.; Wang, X.; Tang, J.;* Yang, Y.-W.* Tuning the Growth, Crosslinking, and Gating Effect of Disulfide-Containing PGMAs on the Surfaces of Mesoporous Silica Nanoparticles for Redox/pH Dual-Controlled Cargo Release. Polym. Chem. 2016, 7, 2171–2179.
************2017************
Xiao Wang （王晓）
B.S. Nanjing Normal University
Research Direction: Single molecule detection and single particle catalysis
1. Ma, Y.‡; Wang, X.‡; Liu, H.; Wei, L.; Xiao, L.* Recent Advances of Optical Microscopic Methods for Single-Particle Tracking in Biological Samples. Anal. Bioanal. Chem. 2019, DOI: https://doi.org/10.1007/s00216-019-01638-z.
Master Students
************2019************
Mengtian Chen (陈梦恬)
B.S. NanKai University
Research Direction: Single-particle catalysis
Yujun Ning (宁钰君)
B.S. Ocean University of China
Research Direction: Super-resolution imaging
************2018************
Tianyu Chen （陈天宇）
B.S. Tianjing Normal University
Research Direction: Single molecule detection
Mengna Huang （黄梦娜）
M.S. Hunan Normal University
Research Direction: Single molecule detection
Ziyi Song（宋子怡）
M.S. Tianjin University
Research Direction: Single molecule imaging
Zhenzhen Li （李珍珍）
M.S. Tianjin University
Research Direction: Single molecule imaging
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Alumni
************2017-09—2020-06************
Zhongju Ye (Ph.D.)
Yuanyuan Ma (M.S.)
Shuming Wang (M.S.)
Ting Zhang (M.S.)
************2016-09—2019-06************
Di Zhang (M.S.)
Fang Qi (M.S.)
Liangna He (M.S.)
************2015-09—2018-06************
Yanhong Ma (M.S.)
Xue Li (M.S.)
Lanlan Pan (M.S.)
Zunyan Yi (M.S.)
************2014-09—2017-06************
Meile Zhong (M.S.)
Xuanfang Zheng (M.S.)
Ziang Zhang (M.S.)
Jianghong Xu (M.S.)
Zhongju Ye (M.S.)
************2013-09—2016-06************
Wenjuan Luo (M.S.)
Qingxiu Yang (M.S.)
Qiaoyu Yang (M.S.)
************2012-09—2015-06************
Peng Zhou (M.S.)
Xin Zhao (M.S.)